Thrombocytopenia-associated multi-organ failure secondary to hyperglycemic, hyperosmolar non-ketotic syndrome: A case report

Pediatr Diabetes. 2018 May;19(3):574-577. doi: 10.1111/pedi.12608. Epub 2017 Nov 22.


Thrombocytopenia associated multi-organ failure (TAMOF) is a clinical syndrome with features of new onset thrombocytopenia, increased lactate dehydrogenase, and multi-organ failure in critically ill patients. TAMOF can be the initial presentation of an underlying disease process or can develop during the course of illness either during the hospital stay. TAMOF has a high mortality rate if not treated; therefore, early detection is critical. TAMOF has been rarely reported in diabetic ketoacidosis. We are describing the first case of a patient diagnosed with hyperglycemic, hyperosmolar non-ketotic syndrome who developed TAMOF on the third day of his hospital course. In addition to supportive care in the intensive care unit the patient received serial therapeutic plasma exchanges and improved quickly after treatment. Early diagnosis and treatment of TAMOF decreases morbidity and mortality.

Keywords: Hyperglycemia; hyperosmolar non-ketotic syndrome; pediatric; plasmapheresis; thrombocytopenia-associated multi-organ failure (TAMOF).

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Humans
  • Hyperglycemic Hyperosmolar Nonketotic Coma / complications*
  • Male
  • Multiple Organ Failure / etiology*
  • Thrombocytopenia / etiology*