68Ga-Prostate-Specific Membrane Antigen Uptake in Gastrointestinal Stromal Tumor

Clin Nucl Med. 2018 Jan;43(1):60-61. doi: 10.1097/RLU.0000000000001902.

Abstract

A 62-year-old man with recently diagnosed prostatic adenocarcinoma was referred for a whole-body Ga-prostate-specific membrane antigen (PSMA) PET/CT scan for staging. Although the scan did not reveal metastatic disease, it did reveal a PSMA-avid lesion in the upper abdomen located between the liver and the stomach. Histopathologic examination demonstrated a gastrointestinal stromal tumor. The lesion demonstrated increased uptake in the margins of the tumor with a central photopenic area, which we consider to be the typical pattern on PSMA images of a gastrointestinal stromal tumor, based on theoretical PSMA distribution in such a tumor and other reported cases.

Publication types

  • Case Reports

MeSH terms

  • Biological Transport
  • Edetic Acid / analogs & derivatives*
  • Edetic Acid / metabolism
  • Gastrointestinal Neoplasms / diagnostic imaging
  • Gastrointestinal Neoplasms / metabolism*
  • Gastrointestinal Stromal Tumors / diagnostic imaging
  • Gastrointestinal Stromal Tumors / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Oligopeptides / metabolism*
  • Positron Emission Tomography Computed Tomography
  • Whole Body Imaging

Substances

  • Oligopeptides
  • Edetic Acid
  • Glu-NH-CO-NH-Lys-(Ahx)-((68)Ga(HBED-CC))