The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis

Cell Adh Migr. 2018;12(6):529-537. doi: 10.1080/19336918.2017.1405208. Epub 2017 Dec 29.


The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extrinsic factors of the tumour stroma, such as the ECM and ECM remodelling; together determine the fate and behaviour of cancer cells. As a consequence, tumour progression, metastatic spread and response to therapy are ultimately controlled by ECM-driven fine-tuning of intracellular kinase signalling. The ability to target and uncouple this interaction presents an emerging and promising potential in the treatment of cancer.

Keywords: Cancer; Extracellular Matrix; Kinase Signalling; Lysyl Oxidase; Metastasis; Remodelling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Extracellular Matrix / metabolism
  • Extracellular Matrix / pathology*
  • Homeostasis / physiology
  • Humans
  • Neoplasm Metastasis / pathology*
  • Neoplasms / pathology*
  • Signal Transduction / physiology*
  • Tumor Microenvironment / physiology