A Case of Benign Phyllodes Tumor in a Transgender Woman Receiving Cross-Sex Hormones

Int J Surg Pathol. 2018 Jun;26(4):356-359. doi: 10.1177/1066896917743011. Epub 2017 Nov 23.


Phyllodes tumor is a relatively uncommon fibroepithelial neoplasm of the breast characterized by proliferation of both stromal and epithelial elements. Benign phyllodes tumors are distinguished from fibroadenomas by their prominent leaf-like architecture and exaggerated intracanalicular stromal growth pattern. Typically, these lesions affect older natal females; however, we present what we believe is the first reported case of benign phyllodes tumor in a hormonally treated transgender woman.

Keywords: benign phyllodes tumor; transgender.

Publication types

  • Case Reports

MeSH terms

  • Androgen Antagonists / adverse effects*
  • Breast Neoplasms / chemically induced*
  • Breast Neoplasms / pathology
  • Estrogens / adverse effects*
  • Female
  • Humans
  • Male
  • Phyllodes Tumor / chemically induced*
  • Phyllodes Tumor / pathology
  • Transgender Persons*


  • Androgen Antagonists
  • Estrogens