Acquisition of the mcr-1 gene by a high-risk clone of KPC-2-producing Klebsiella pneumoniae ST437/CC258, Brazil

Diagn Microbiol Infect Dis. 2018 Feb;90(2):132-133. doi: 10.1016/j.diagmicrobio.2017.09.016. Epub 2017 Oct 5.

Abstract

We identified one clinical isolate of K. pneumoniae harboring the mcr 1 (plasmid of IncX4 family) and blaKPC-2 (plasmid of IncFIB family) genes in southern Brazil. These findings highlight that K. pneumoniae isolates carrying both mcr-1 and blaKPC-2 may emergence as a serious threat to antimicrobial therapy.

Keywords: Carbapenems; Colistin; Klebsiella pneumoniae; Resistance genes.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Brazil
  • Carbapenems / pharmacology*
  • Colistin / pharmacology*
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Humans
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics*
  • Microbial Sensitivity Tests
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • beta-Lactamases
  • Colistin