Mind-Matter Interactions and the Frontal Lobes of the Brain: A Novel Neurobiological Model of Psi Inhibition

Explore (NY). 2018 Jan-Feb;14(1):76-85. doi: 10.1016/j.explore.2017.08.003. Epub 2017 Oct 23.


Context: Despite a large literature on psi, which encompasses a range of experiences including putative telepathy (mind-mind connections), clairvoyance (perceiving distant objects or events), precognition (perceiving future events), and mind-matter interactions, there has been insufficient focus on the brain in relation to this controversial phenomenon. In contrast, our research is based on a novel neurobiological model suggesting that frontal brain systems act as a filter to inhibit psi and that the inhibitory mechanisms may relate to self-awareness.

Objective: To identify frontal brain regions that may inhibit psi.

Design: We used mind-matter interactions to study psi in two participants with frontal lobe damage. The experimental task was to influence numerical output of a Random Event Generator translated into movement of an arrow on a computer screen to the right or left. Brain MRI was analyzed to determine frontal volume loss.

Results: The primary area of lesion overlap between the participants was in the left medial middle frontal region, an area related to self-awareness, and involved Brodmann areas 9, 10, and 32. Both participants showed a significant effect in moving the arrow to the right, i.e., contralateral to the side of primary lesion overlap. Effect sizes were much larger compared to normal participants.

Conclusions: The medial frontal lobes may act as a biological filter to inhibit psi through mechanisms related to self-awareness. Neurobiological studies with a focus on the brain may open new avenues of research on psi and may significantly advance the state of this poorly understood field.

Keywords: anomalous cognition; frontal lobes; mind–matter interactions; parapsychology; psi filter; self-awareness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Awareness
  • Female
  • Frontal Lobe / diagnostic imaging
  • Frontal Lobe / pathology*
  • Frontotemporal Dementia / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Parapsychology*
  • Pneumocephalus / pathology