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, 158 (2), 569-75

Molecular Cloning and Nucleotide Sequence of Human Pancreatic Prechymotrypsinogen cDNA

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Molecular Cloning and Nucleotide Sequence of Human Pancreatic Prechymotrypsinogen cDNA

N Tomita et al. Biochem Biophys Res Commun.

Abstract

The cDNA clone encoding human prechymotrypsinogen was isolated from a human pancreas cDNA library and its nucleotide sequence was determined. The sequence consists of a 16 bp 5' non-coding region, a 789 bp amino acid coding region and a 60 bp 3' non-coding region. The predicted product consists of 263 amino acids, including 18 amino acids for a signal peptide and 15 amino acids possible for an activation peptide. Southern blot analyses using the cloned cDNA as a probe revealed that human genomic DNA carries at least two genes that are related to chymotrypsinogen.

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