Anticoagulation Therapies in Children

Abstract

Venous thromboembolism is occurring with increasing frequency in children resulting in the more widespread use of anticoagulation in pediatrics. Antithrombotic drugs in children can be divided into the standard and alternative agents. This review discusses standard and alternative anticoagulants. Because standard anticoagulants have significant limitations, including variable pharmacokinetics, issues with therapeutic drug monitoring, frequency of administration, efficacy, and adverse effects, it is expected that the use of alternative anticoagulants will increase over time. With their improved properties and recent prospective clinical trial data, the current and future use of these agents will likely slowly replace of the standard anticoagulants.

Keywords: Anticoagulation; Argatroban; Bivalirudin; Children; Fondaparinux; Heparin; Low-molecular-weight heparin; Warfarin.