[Dose adaptation of the drugs used for hematopoietic stem-cell transplantation in patients with comorbidity: Obesity, chronic renal disease or hepatopathy: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)]

Bull Cancer. 2017 Dec;104(12S):S99-S105. doi: 10.1016/j.bulcan.2017.07.010. Epub 2017 Nov 23.
[Article in French]

Abstract

In September 2016 in Lille, France, the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) organized the 7th Allogeneic Stem Cell Transplantation Clinical Practices Harmonization Workshop Series. Our work group focused on chemotherapy drug dose adaptation for hematopoietic stem cell transplantation patients presenting a comorbidity. The purpose of this workshop was to provide recommendations on chemotherapy drug dose adaptation for patient populations receiving hematopoietic stem cell transplantation who also had the following comorbidities: obesity, chronic kidney disease and hepatopathy.

Keywords: Allogeneic stem cell transplantation; Allogreffe de cellules souches hématopoïétiques; Chronic kidney disease; Comorbidity; Comorbidité; Hepatopathy; Hépatopathie; Maladie rénale chronique; Obesity; Obésité.

Publication types

  • Consensus Development Conference
  • Practice Guideline
  • Review

MeSH terms

  • Adult
  • Age Factors
  • Busulfan / administration & dosage
  • Child
  • Comorbidity
  • Cyclophosphamide / administration & dosage
  • Etoposide / administration & dosage
  • France
  • Hematopoietic Stem Cell Transplantation / standards*
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Liver Diseases* / epidemiology
  • Melphalan / administration & dosage
  • Obesity* / epidemiology
  • Renal Insufficiency, Chronic* / epidemiology
  • Societies, Medical
  • Surveys and Questionnaires
  • Thiotepa / administration & dosage
  • Transplantation Conditioning / standards*
  • Vidarabine / administration & dosage
  • Vidarabine / analogs & derivatives
  • Whole-Body Irradiation

Substances

  • Immunosuppressive Agents
  • Etoposide
  • Cyclophosphamide
  • Thiotepa
  • Vidarabine
  • Busulfan
  • fludarabine
  • Melphalan