A domain-based DNA circuit for smart single-nucleotide variant identification

Chem Commun (Camb). 2018 Feb 1;54(11):1311-1314. doi: 10.1039/c7cc07733e.

Abstract

According to the differential information of four homologous oligonucleotides, two domain-based encoders have been constructed with the molecular information as the input. Based on the one-to-one correspondence between the input and output, SNVs can be identified and their sites can be located at the domain level.

MeSH terms

  • Alkanesulfonates / chemistry
  • Azo Compounds / chemistry
  • Computers, Molecular*
  • DNA / genetics*
  • Fluoresceins / chemistry
  • Fluorescence
  • Nucleic Acid Hybridization
  • Oligodeoxyribonucleotides / analysis*
  • Oligodeoxyribonucleotides / genetics
  • Polymorphism, Single Nucleotide*

Substances

  • Alkanesulfonates
  • Azo Compounds
  • BHQ-1 compound
  • Fluoresceins
  • Oligodeoxyribonucleotides
  • 6-carboxyfluorescein
  • DNA