Novel pathomechanisms in inflammatory neuropathies

J Neuroinflammation. 2017 Nov 28;14(1):232. doi: 10.1186/s12974-017-1001-8.


Inflammatory neuropathies are rare autoimmune-mediated disorders affecting the peripheral nervous system. Considerable progress has recently been made in understanding pathomechanisms of these disorders which will be essential for developing novel diagnostic and therapeutic strategies in the future. Here, we summarize our current understanding of antigenic targets and the relevance of new immunological concepts for inflammatory neuropathies. In addition, we provide an overview of available animal models of acute and chronic variants and how new diagnostic tools such as magnetic resonance imaging and novel therapeutic candidates will benefit patients with inflammatory neuropathies in the future. This review thus illustrates the gap between pre-clinical and clinical findings and aims to outline future directions of development.

Keywords: Animal model; Chronic inflammatory demyelinating polyneuropathy; Experimental autoimmune neuritis; Guillain-Barré syndrome; Th17 cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Guillain-Barre Syndrome / physiopathology*
  • Humans
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / physiopathology*