Prevalence of antibodies and humoral response after seasonal trivalent vaccination against influenza B lineages in an elderly population of Spain

Enferm Infecc Microbiol Clin (Engl Ed). 2018 Nov;36(9):572-575. doi: 10.1016/j.eimc.2017.10.021. Epub 2017 Nov 26.
[Article in English, Spanish]


Introduction: The aim of this study was to analyze the presence of antibodies against both Yamagata and Victoria influenza B lineages and to check the response after seasonal trivalent vaccination.

Materials and methods: Haemagglutination inhibition assays were performed with pre-and post-vaccination serum samples from 174 individuals ≥65 years of age vaccinated with seasonal trivalent influenza vaccines during the 2006-2007, 2008-2009, 2009-2010 and 2010-2011 vaccine campaigns.

Results: 33.9% of individuals showed pre-vaccine protective antibodies (≥1/40) against B/Yamagata lineage and 41.4% against B/Victoria lineage. The annual trivalent vaccine induced significant homologous seroconversion in 14-35.6% of individuals in each vaccine campaign.

Conclusions: The population ≥65 years has low-moderate seroprotection against B influenza lineages. Trivalent vaccination induced a slight increase of seroprotection. The trivalent vaccine should be administered to all individuals ≥65 years in all vaccine campaigns.

Keywords: Antibodies; Anticuerpos; Influenza B lineages; Linajes de gripe B; Trivalent influenza vaccination; Vacuna trivalente de gripe.

MeSH terms

  • Aged
  • Antibodies, Viral / blood*
  • Female
  • Hemagglutination Inhibition Tests
  • Humans
  • Immunogenicity, Vaccine*
  • Influenza B virus / classification
  • Influenza B virus / immunology*
  • Influenza Vaccines / immunology*
  • Influenza, Human / prevention & control
  • Male
  • Seasons
  • Spain / epidemiology
  • Vaccination*


  • Antibodies, Viral
  • Influenza Vaccines