Modulating Neuroinflammation to Treat Neuropsychiatric Disorders

Biomed Res Int. 2017:2017:5071786. doi: 10.1155/2017/5071786. Epub 2017 Oct 18.


Neuroinflammation is recognised as one of the potential mechanisms mediating the onset of a broad range of psychiatric disorders and may contribute to nonresponsiveness to current therapies. Both preclinical and clinical studies have indicated that aberrant inflammatory responses can result in altered behavioral responses and cognitive deficits. In this review, we discuss the role of inflammation in the pathogenesis of neuropsychiatric disorders and ask the question if certain genetic copy-number variants (CNVs) associated with psychiatric disorders might play a role in modulating inflammation. Furthermore, we detail some of the potential treatment strategies for psychiatric disorders that may operate by altering inflammatory responses.

Publication types

  • Review

MeSH terms

  • Cognitive Dysfunction* / genetics
  • Cognitive Dysfunction* / metabolism
  • Cognitive Dysfunction* / physiopathology
  • Cognitive Dysfunction* / therapy
  • Genetic Variation*
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism
  • Inflammation / physiopathology
  • Inflammation / therapy