An update on vinpocetine: New discoveries and clinical implications

Eur J Pharmacol. 2018 Jan 15;819:30-34. doi: 10.1016/j.ejphar.2017.11.041. Epub 2017 Nov 26.

Abstract

Vinpocetine, a derivative of the alkaloid vincamine, has been clinically used in many countries for treatment of cerebrovascular disorders such as stroke and dementia for more than 30 years. Currently, vinpocetine is also available in the market as a dietary supplement to enhance cognition and memory. Due to its excellent safety profile, increasing efforts have been put into exploring the novel therapeutic effects and mechanism of actions of vinpocetine in various cell types and disease models. Recent studies have revealed a number of novel functions of vinpocetine, including anti-inflammation, antagonizing injury-induced vascular remodeling and high-fat-diet-induced atherosclerosis, as well as attenuating pathological cardiac remodeling. These novel findings may facilitate the repositioning of vinpocetine for preventing or treating relevant disorders in humans.

Keywords: Cardiovascular; Inflammation; Neurovascular; Vinpocetine.

Publication types

  • Review

MeSH terms

  • Animals
  • Heart Diseases / drug therapy
  • Humans
  • Nervous System Diseases / drug therapy
  • Vascular Diseases / drug therapy
  • Vinca Alkaloids* / pharmacology
  • Vinca Alkaloids* / therapeutic use

Substances

  • Vinca Alkaloids
  • vinpocetine