Development and differentiation of early innate lymphoid progenitors

J Exp Med. 2018 Jan 2;215(1):249-262. doi: 10.1084/jem.20170832. Epub 2017 Nov 28.

Abstract

Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor-successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps). Functional, bioinformatic, phenotypical, and genetic approaches collectively establish EILPs as an intermediate progenitor between ALPs and ILCps. Our work additionally provides new candidate regulators of ILC development and clearly defines the stage of requirement of transcription factors key for early ILC development.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Biomarkers
  • Bone Marrow Cells / cytology
  • Bone Marrow Cells / immunology
  • Bone Marrow Cells / metabolism
  • Cell Differentiation*
  • Cytokines / metabolism
  • GATA3 Transcription Factor / metabolism
  • Gene Expression Profiling
  • Immunity, Innate*
  • Immunophenotyping
  • Lymphocyte Subsets / cytology
  • Lymphocyte Subsets / immunology
  • Lymphocyte Subsets / metabolism
  • Lymphoid Progenitor Cells / cytology*
  • Lymphoid Progenitor Cells / immunology
  • Lymphoid Progenitor Cells / metabolism*
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Phenotype

Substances

  • Biomarkers
  • Cytokines
  • GATA3 Transcription Factor
  • Gata3 protein, mouse