The human pegivirus: A new name for an "ancient" virus. Can transfusion medicine come up with something new?

Acta Virol. 2017;61(4):401-412. doi: 10.4149/av_2017_402.


Human pegivirus (HPgV, formerly called GB virus C/hepatitis G virus) is a poorly understood RNA virus of the Flaviviridae family. The HPgV infection is common worldwide and the virus is likely transmitted by blood products. At this time, no causal association between HPgV and human diseases has been identified. While waiting for new findings to better understand the Pegivirus genus, the aim of our narrative review is to discuss the currently available information on HPgV focusing on its prevalence in blood donors and its potential threat to transfusion safety.

Keywords: GB virus type C; hepatitis G virus; human pegivirus; Flaviviridae; hepatitis; blood transfusion..

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Safety / standards*
  • Blood Transfusion
  • Flaviviridae / genetics
  • Flaviviridae / physiology*
  • Flaviviridae Infections / transmission*
  • Flaviviridae Infections / virology
  • Humans
  • Transfusion Medicine / methods
  • Transfusion Medicine / standards*