Growth Restriction, Osteopenia, Placental Massive Perivillous Fibrin Deposition With (or Without) Intervillous Histiocytes and Renal Tubular Dysgenesis-An Emerging Complex

Pediatr Dev Pathol. 2018 Jan-Feb;21(1):91-94. doi: 10.1177/1093526617697061. Epub 2017 Mar 15.


We describe a case of a pregnancy complicated by early onset asymmetric growth restriction with anhydramnios with termination occurring at 21 weeks. Fetal autopsy showed demineralization of bones and renal tubular dysgenesis. Placental pathology showed features of massive perivillous fibrin deposition and chronic histiocytic intervillositis. We review prior documentation of this association and briefly discuss potential pathogenesis.

Keywords: chronic intervillosistis; fetal; intrauterine growth restriction; massive perivillous fibrin; placenta; renal tubular dysgenesis.

Publication types

  • Case Reports
  • Letter
  • Review

MeSH terms

  • Abortion, Eugenic
  • Adult
  • Bone Diseases, Metabolic / diagnosis*
  • Bone Diseases, Metabolic / pathology
  • Female
  • Fetal Growth Retardation / diagnosis*
  • Fetal Growth Retardation / pathology
  • Humans
  • Kidney Tubules, Proximal / abnormalities*
  • Kidney Tubules, Proximal / pathology
  • Male
  • Placenta Diseases / diagnosis*
  • Placenta Diseases / pathology
  • Pregnancy
  • Syndrome
  • Urogenital Abnormalities / diagnosis*
  • Urogenital Abnormalities / pathology

Supplementary concepts

  • Allanson Pantzar McLeod syndrome