Heterotypic Ubiquitin Chains: Seeing is Believing

Trends Cell Biol. 2018 Jan;28(1):1-3. doi: 10.1016/j.tcb.2017.11.005. Epub 2017 Nov 27.


The biological diversity of ubiquitination resides in the multivalent nature of linkage-specific homotypic and heterotypic ubiquitin (Ub) chains. A recent publication by Yau et al. in Cell describes the development of K11/K48-bispecific antibodies and a physiological role for K11/K48 heterotypic chains in regulation of the cell cycle and clearance of aggregated proteins.

Keywords: APC/C; Huntingtin (HTT); K11/K48 branched; heterotypic Ub chain; ubiquitin.

Publication types

  • Comment

MeSH terms

  • Cell Cycle
  • Ubiquitin*
  • Ubiquitination*


  • Ubiquitin