Cyclic Guanosine Monophosphate-Dependent Protein Kinase I Stimulators and Activators Are Therapeutic Alternatives for Sickle Cell Disease

Turk J Haematol. 2018 Mar 1;35(1):77-78. doi: 10.4274/tjh.2017.0407. Epub 2017 Dec 1.

Authors

Mohankrishna Ghanta¹, Elango Panchanathan¹, Bhaskar Vks Lakkakula²

Affiliations

¹ Sri Ramachandra Medical College and Research Institute-DU, Faculty of Medicine, Department of Pharmacology, Chennai, Tamil Nadu, India.
² Sickle Cell Institute Chhattisgarh, Department of Molecular Genetics, Division of Research, Raipur, Chhattisgarh, India.

No abstract available

Keywords: Sickle cell anemia; cGK activation Nitric oxide..

Publication types

Letter

MeSH terms

Anemia, Sickle Cell / drug therapy*
Anemia, Sickle Cell / metabolism*
Anemia, Sickle Cell / pathology
Antisickling Agents / pharmacology
Antisickling Agents / therapeutic use
Cyclic GMP-Dependent Protein Kinase Type I / metabolism*
Drug Discovery
Humans
Nitric Oxide / metabolism
Signal Transduction / drug effects

Substances

Antisickling Agents
Nitric Oxide
Cyclic GMP-Dependent Protein Kinase Type I