Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms

Phytother Res. 2018 Jan;32(1):84-93. doi: 10.1002/ptr.5951. Epub 2017 Nov 29.


The metabolic syndrome (MetS) is a multicomponent condition with a complex etiology involving genetic and environmental factors. Artichoke leaf extract (ALE) has shown favorable effects on lipid and glucose metabolism. The present study aimed to investigate the effects of ALE supplementation on metabolic parameters in women with MetS, using a nutrigenetics approach. In this double-blind randomized clinical trial, 50 women (aged 20-50 years) with MetS were randomly allocated into the two groups: "ALE group" (received 1,800 mg hydroalcoholic extract of artichoke as four tablets per day) and "placebo group" (received placebo consisted of corn starch, lactose, and avicel as four tablets per day) for 12 weeks. The biochemical and anthropometric parameters were determined before and after the intervention. The FTO-rs9939609 and the TCF7L2-rs7903146 polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism. In carriers of A allele of the FTO-rs9939609, ALE supplementation resulted in a statistically significant decrease in serum triglyceride level compared with placebo (-19.11% vs. 10.83%; p < .05), with no other significant differences between the two groups. The TCF7L2-rs7903146 polymorphism showed no interaction with response to ALE (p > .05). These findings suggest that ALE supplementation may improve serum triglyceride level in A allele genotype of FTO-rs9939609 polymorphism in women with MetS.

Keywords: FTO; TCF7L2; artichoke leaf extract; metabolic syndrome; nutrigenetics.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO / metabolism*
  • Cynara scolymus / chemistry*
  • Double-Blind Method
  • Female
  • Genotype
  • Humans
  • Male
  • Metabolic Syndrome / drug therapy*
  • Metabolic Syndrome / pathology
  • Middle Aged
  • Polymorphism, Genetic
  • Transcription Factor 7-Like 2 Protein / metabolism*
  • Young Adult


  • TCF7L2 protein, human
  • Transcription Factor 7-Like 2 Protein
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO
  • FTO protein, human