Prenatal thrombosis of renal veins and the inferior vena cava in a newborn with double heterozygosity for the factor V Leiden and prothrombin gene G20210A mutations: a case report

Blood Coagul Fibrinolysis. 2018 Mar;29(2):220-222. doi: 10.1097/MBC.0000000000000686.

Abstract

: Renal vein thrombosis in a neonate is a rare but well recognized condition with low mortality but high morbidity. The cause has not been explained clearly yet but is probably a multifactorial process that includes inherited prothrombotic abnormalities. Antenatal onset of renal vein thrombosis is important due to the increased risk for permanent organ damage. We report a case of prenatal thrombosis of the renal veins and the inferior vena cava in a newborn with double heterozygosity for factor V Leiden and prothrombin gene mutations who had persistently impaired renal function requiring chronic peritoneal dialysis.

Publication types

  • Case Reports

MeSH terms

  • Factor V / genetics*
  • Heterozygote
  • Humans
  • Infant, Newborn
  • Male
  • Prothrombin / genetics*
  • Renal Veins / abnormalities*
  • Thrombosis / genetics*
  • Vena Cava, Inferior / abnormalities*

Substances

  • factor V Leiden
  • Factor V
  • Prothrombin