Mathematical model for studying genetic variation in terms of restriction endonucleases

Proc Natl Acad Sci U S A. 1979 Oct;76(10):5269-73. doi: 10.1073/pnas.76.10.5269.


A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide substitutions between two populations or species. To express the degree of polymorphism in a population at the nucleotide level, a measure called "nucleotide diversity" is proposed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Computers
  • DNA Restriction Enzymes*
  • DNA, Mitochondrial*
  • Genetic Variation*
  • Mathematics
  • Models, Biological


  • DNA, Mitochondrial
  • DNA Restriction Enzymes