[Effect of estradiol dipropionate on the development of uterine sarcoma induced by 1,2-dimethylhydrazine in mice]

Vopr Onkol. 1989;35(1):52-7.
[Article in Russian]

Abstract

The study was concerned with the influence of single dose of estradiol dipropionate on its promoting effect on 1,2-dimethylhydrazine-induced tumors in female CBA/CaLac mice. Estradiol dipropionate given within 19 weeks did not affect carcinogenesis whereas 39-week treatment stimulated uterine sarcoma development irrespective of single dose and schedule of administration.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • 1,2-Dimethylhydrazine
  • Alleles
  • Animals
  • Carcinogens
  • Cocarcinogenesis*
  • Dimethylhydrazines / toxicity*
  • Estradiol / analogs & derivatives*
  • Estradiol / toxicity
  • Female
  • Genotype
  • Methylhydrazines / toxicity*
  • Mice
  • Mice, Inbred CBA / genetics
  • Sarcoma, Experimental / chemically induced*
  • Sarcoma, Experimental / epidemiology
  • Time Factors
  • Uterine Neoplasms / chemically induced*
  • Uterine Neoplasms / epidemiology

Substances

  • Carcinogens
  • Dimethylhydrazines
  • Methylhydrazines
  • Estradiol
  • 1,2-Dimethylhydrazine
  • estradiol dipropionate