GDF15-From Biomarker to Allostatic Hormone
- PMID: 29195860
- DOI: 10.1016/j.cmet.2017.10.017
GDF15-From Biomarker to Allostatic Hormone
Abstract
With the identification of its receptor in a highly specific region of the brain, interesting issues come to light regarding the normal physiological functions of GDF15, a secreted protein long identified as a biomarker of diverse disease states.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
-
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.Nat Med. 2017 Oct;23(10):1150-1157. doi: 10.1038/nm.4392. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846097
Similar articles
-
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.Nat Med. 2017 Oct;23(10):1150-1157. doi: 10.1038/nm.4392. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846097
-
The first multi-zoo application of an allostatic load index to western lowland gorillas (Gorilla gorilla gorilla).Gen Comp Endocrinol. 2018 Sep 15;266:135-149. doi: 10.1016/j.ygcen.2018.05.006. Epub 2018 May 7. Gen Comp Endocrinol. 2018. PMID: 29746855
-
Allostasis and allostatic load: expanding the discourse on stress and cardiovascular disease.J Clin Nurs. 2008 Apr;17(7B):201-8. doi: 10.1111/j.1365-2702.2008.02347.x. J Clin Nurs. 2008. PMID: 18578796 Review.
-
Biomarkers of homeostasis, allostasis, and allostatic overload in decapod crustaceans of distinct habitats and osmoregulatory strategies: an empirical approach.Comp Biochem Physiol A Mol Integr Physiol. 2020 Oct;248:110750. doi: 10.1016/j.cbpa.2020.110750. Epub 2020 Jun 25. Comp Biochem Physiol A Mol Integr Physiol. 2020. PMID: 32592759
-
Allostatic Load and Biomarkers of Stress in the Preterm Infant: An Integrative Review.Biol Res Nurs. 2019 Mar;21(2):210-223. doi: 10.1177/1099800418824415. Epub 2019 Jan 17. Biol Res Nurs. 2019. PMID: 30654634 Review.
Cited by
-
GDF15: A Hormone Conveying Somatic Distress to the Brain.Endocr Rev. 2020 Aug 1;41(4):bnaa007. doi: 10.1210/endrev/bnaa007. Endocr Rev. 2020. PMID: 32310257 Free PMC article. Review.
-
Growth differentiation factor 15 (GDF15) is associated with non-alcoholic fatty liver disease (NAFLD) in youth with overweight or obesity.Nutr Diabetes. 2022 Feb 22;12(1):9. doi: 10.1038/s41387-022-00187-2. Nutr Diabetes. 2022. PMID: 35194014 Free PMC article.
-
GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss.Cell Rep. 2020 Apr 21;31(3):107543. doi: 10.1016/j.celrep.2020.107543. Cell Rep. 2020. PMID: 32320650 Free PMC article.
-
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi: 10.1016/j.cmet.2018.12.016. Epub 2019 Jan 10. Cell Metab. 2019. PMID: 30639358 Free PMC article.
-
"Treasure Your Exceptions"-Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture.Diabetes. 2021 Jan;70(1):29-38. doi: 10.2337/dbi19-0037. Diabetes. 2021. PMID: 33355307 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
