A Randomized Double-Blinded Placebo-Controlled Intervention Trial of Melatonin for the Prevention of Preeclampsia in Moderate- and High-Risk Women: The MELPOP Trial

Methods Mol Biol. 2018;1710:347-352. doi: 10.1007/978-1-4939-7498-6_28.

Abstract

This chapter describes the methodologies which may be used in the development of a randomized controlled trial investigating a therapy of choice in preventing preeclampsia.

Keywords: Clinical trial; Melatonin; Oxidative stress; Preeclampsia; Prevention.

MeSH terms

  • Antioxidants / administration & dosage
  • Antioxidants / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Melatonin / administration & dosage
  • Melatonin / therapeutic use*
  • Oxidative Stress / drug effects
  • Placebo Effect
  • Pre-Eclampsia / metabolism
  • Pre-Eclampsia / prevention & control*
  • Pregnancy
  • Randomized Controlled Trials as Topic / methods*

Substances

  • Antioxidants
  • Melatonin