Fantastic Beasts and How To Sequence Them: Ecological Genomics for Obscure Model Organisms

Trends Genet. 2018 Feb;34(2):121-132. doi: 10.1016/j.tig.2017.11.002. Epub 2017 Nov 29.


The application of genomic approaches to 'obscure model organisms' (OMOs), meaning species with no prior genomic resources, enables increasingly sophisticated studies of the genomic basis of evolution, acclimatization, and adaptation in real ecological contexts. I consider here ecological questions that can be addressed using OMOs, and indicate optimal sequencing and data-handling solutions for each case. With this I hope to promote the diversity of OMO-based projects that would capitalize on the peculiarities of the natural history of OMOs and could feasibly be completed within the scope of a single PhD thesis.

Publication types

  • Review

MeSH terms

  • Adaptation, Biological / genetics
  • Animals
  • Biological Evolution
  • DNA Methylation
  • Ecology
  • Gene Ontology
  • Genetics, Population*
  • Genome*
  • Genomics / instrumentation
  • Genomics / methods*
  • High-Throughput Nucleotide Sequencing / economics
  • High-Throughput Nucleotide Sequencing / methods*
  • High-Throughput Nucleotide Sequencing / trends
  • Models, Animal*
  • Molecular Sequence Annotation