Platelet-derived chemokines in inflammation and atherosclerosis

Cytokine. 2019 Oct:122:154157. doi: 10.1016/j.cyto.2017.09.013. Epub 2017 Dec 1.


Platelets are inflammatory anuclear cells with a well-established role in the development and manifestation of atherosclerosis. Activated platelets secrete a plethora of chemokines including CXCL4 or platelet factor 4 (PF4), CCL5, CXCL12 or stromal cell derived factor-1α (SDF-1α), CXCL16 and others, which initiate or promote local inflammatory processes at sites of vascular injury. These processes are mainly mediated by the recruitment of circulating haematopoietic stem cells, neutrophils, monocytes or lymphocytes on vascular wall. Under acute ischemic conditions platelet-derived chemokines may promote the mobilization of bone marrow-derived progenitor cells and their homing at lesion sites. This review focuses on the role of platelet-derived chemokines in inflammation and atherosclerosis. Further, we discuss the clinical value of plasma levels of chemokines in the prognosis of atherosclerotic heart disease.

Keywords: Atherosclerosis; Chemokines; Coronary artery disease; Inflammation; Platelets.

Publication types

  • Review

MeSH terms

  • Animals
  • Atherosclerosis / metabolism*
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism*
  • Chemokine CCL5 / metabolism
  • Chemokine CXCL12 / metabolism
  • Chemokine CXCL16 / metabolism
  • Chemokines / metabolism*
  • Coronary Artery Disease / metabolism
  • Humans
  • Inflammation / immunology
  • Inflammation / metabolism*
  • Monocytes / metabolism
  • Platelet Activation / immunology
  • Platelet Factor 4 / metabolism
  • Risk Factors


  • CCL5 protein, human
  • CXCL12 protein, human
  • CXCL16 protein, human
  • Chemokine CCL5
  • Chemokine CXCL12
  • Chemokine CXCL16
  • Chemokines
  • PF4 protein, human
  • Platelet Factor 4