Spinal Cord Injuries and Nerve Dependence in Prostate Cancer

Alison Rutledge; Phillip Jobling; Marjorie M Walker; Jim W Denham; Hubert Hondermarck

doi:10.1016/j.trecan.2017.10.001

Spinal Cord Injuries and Nerve Dependence in Prostate Cancer

Trends Cancer. 2017 Dec;3(12):812-815. doi: 10.1016/j.trecan.2017.10.001. Epub 2017 Nov 6.

Authors

Alison Rutledge¹, Phillip Jobling², Marjorie M Walker³, Jim W Denham³, Hubert Hondermarck⁴

Affiliations

¹ School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW 2305, Australia; Department of Surgery, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
² School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW 2305, Australia.
³ Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW 2305, Australia; School of Public Health and Medicine, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
⁴ School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW 2305, Australia. Electronic address: hubert.hondermarck@newcastle.edu.au.

PMID: 29198437
DOI: 10.1016/j.trecan.2017.10.001

Abstract

Nerves are emerging as drivers of tumorigenesis, as demonstrated in the mouse where denervation suppresses prostate cancer; however, clinical evidence is needed. Patients with spinal cord injuries (SCIs) resulting in functional denervation of the prostate have a lower incidence of prostate cancer. This may constitute a clinical evidence for nerve dependence in human prostate tumorigenesis.

Keywords: cancer; nerve dependence; nerves; prostate; spinal cord injuries.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carcinogenesis / genetics*
Carcinogenesis / pathology
Humans
Male
Mice
Nerve Degeneration / genetics
Nerve Degeneration / physiopathology
Prostate / innervation*
Prostate / physiopathology
Prostatic Neoplasms / genetics*
Prostatic Neoplasms / physiopathology
Spinal Cord / physiopathology
Spinal Cord Injuries / physiopathology*