The Microbiota Regulates Immunity and Immunologic Diseases in Dogs and Cats

Vet Clin North Am Small Anim Pract. 2018 Mar;48(2):307-322. doi: 10.1016/j.cvsm.2017.10.008. Epub 2017 Nov 29.

Abstract

The complex commensal microbiota found on body surfaces controls immune responses and the development of allergic and inflammatory diseases. New genetic technologies permit investigators to determine the composition of the complex microbial populations found on these surfaces. Changes in the microbiota (dysbiosis) as a result of antibiotic use, diet, or other factors thus influence the development of many diseases in the dog and cat. The most important of these include chronic gastrointestinal disease; respiratory allergies, such as asthma; skin diseases, especially atopic dermatitis; and some autoimmune diseases.

Keywords: Allergies; Atopic dermatitis; Autoimmunity; Dysbiosis; Hygiene hypothesis; Microbiota.

Publication types

  • Review

MeSH terms

  • Animals
  • Cat Diseases / immunology*
  • Cat Diseases / microbiology*
  • Cats
  • Dermatitis, Atopic / microbiology
  • Dermatitis, Atopic / veterinary
  • Dog Diseases / immunology*
  • Dog Diseases / microbiology*
  • Dogs
  • Dysbiosis / veterinary
  • Hypersensitivity / microbiology
  • Hypersensitivity / veterinary
  • Inflammatory Bowel Diseases / microbiology
  • Inflammatory Bowel Diseases / veterinary
  • Mice
  • Microbiota / genetics
  • Microbiota / physiology*
  • RNA, Ribosomal, 16S

Substances

  • RNA, Ribosomal, 16S