Treatment of reflux disease during pregnancy and lactation

Turk J Gastroenterol. 2017 Dec;28(Suppl 1):S53-S56. doi: 10.5152/tjg.2017.14.


Gastroesophageal reflux disease (GERD) is frequently seen during pregnancy. In the medical treatment of pregnant women with GERD, alginic acid and sucralfate can be used. Calcium- and magnesium-based antacids can also be used, particularly for patients with preeclampsia. In particular, ranitidine -a histamine-2 receptor blocker- is preferred. In the case of non-responsiveness to the abovementioned treatments, proton pump inhibitors (PPIs), except omeprazole, can be given considering the benefit-harm ratio for the mother and fetus after the first trimester. In cases with GERD during the lactation period, drugs having minimum systemic absorption, such as sucralfate and alginic acid, are preferable but there is no data.

MeSH terms

  • Alginates / therapeutic use*
  • Antacids / therapeutic use*
  • Female
  • Gastroesophageal Reflux / drug therapy*
  • Glucuronic Acid / therapeutic use
  • Hexuronic Acids / therapeutic use
  • Humans
  • Lactation / drug effects*
  • Omeprazole / adverse effects
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Proton Pump Inhibitors / therapeutic use
  • Ranitidine / therapeutic use
  • Sucralfate / therapeutic use*


  • Alginates
  • Antacids
  • Hexuronic Acids
  • Proton Pump Inhibitors
  • Sucralfate
  • Ranitidine
  • Glucuronic Acid
  • Omeprazole