Intermittent fasting and cardiovascular disease: current evidence and unresolved questions

Future Cardiol. 2018 Jan;14(1):47-54. doi: 10.2217/fca-2017-0038. Epub 2017 Dec 4.


Intermittent fasting has produced a variety of beneficial health effects in animal models, although high-quality research in humans has been limited. This special report examines current evidences for intermittent fasting in humans, discusses issues that require further examination, and recommends new research that can improve the knowledge base in this emerging research area. While potentially useful for health improvement, intermittent fasting requires further study prior to widespread implementation for health purposes. Randomized, longer-term studies are needed to determine whether using intermittent fasting as a lifestyle rather than a diet is feasible and beneficial for the health of some members of the human population.

Keywords: alternate-day fasting; calorie restriction; energy restriction; fasting-mimicking diet; intermittent fasting; periodic fasting; time-restricted feeding.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiovascular Diseases* / epidemiology
  • Cardiovascular Diseases* / etiology
  • Cardiovascular Diseases* / prevention & control
  • Fasting*
  • Global Health
  • Humans
  • Incidence
  • Obesity* / complications
  • Obesity* / epidemiology
  • Obesity* / rehabilitation