Promising role for Gc-MAF in cancer immunotherapy: from bench to bedside

Caspian J Intern Med. 2017 Fall;8(4):228-238. doi: 10.22088/cjim.8.4.228.


Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics medications can also enhance immune-cell activity against tumors. Such medications show great potential in cancer immunotherapy using natural human mechanisms against neoplasms.

Keywords: Cancer; Gc-MAF; Immunotherapy; Macrophage activating factor; Vitamin D..

Publication types

  • Review