Human Genomics of Mycobacterium tuberculosis Infection and Disease

Curr Genet Med Rep. 2017 Sep;5(3):125-131. doi: 10.1007/s40142-017-0124-7. Epub 2017 Jul 25.


Purpose of review: The study of the genetic basis of tuberculosis pathogenesis has benefited from powerful technological innovations, a more structured definition of latent and clinical manifestations of the disease, and the application of functional genomics approaches. This short review aims to summarize recent advances and to provide a link with results of previous human genetic studies of tuberculosis susceptibility.

Recent findings: Transcriptomics has been shown to be a useful tool to predict progression from latency to clinical disease while functional genomics has traced the molecular events that link pathogen-triggered gene expression and host genetics. Resistance to infection with Mycobacterium tuberculosis has been revealed to be strongly impacted by host genetics. Host genomics of clinical disease has been shown to be most powerful when focusing on carefully selected clinical entities and possibly by considering host pathogen combinations.

Summary: Future studies need to build on the latest molecular findings to define disease subtypes to successfully elucidate the human genetic component in tuberculosis pathogenesis.

Keywords: functional genomics of tuberculosis; host genomics of tuberculosis; human genetics of infection; transcript biomarkers; tuberculosis.