Patterns of grey matter loss associated with motor subscores in early Parkinson's disease

Neuroimage Clin. 2017 Nov 10;17:498-504. doi: 10.1016/j.nicl.2017.11.009. eCollection 2018.

Abstract

Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether parkinsonian motor symptoms are associated with different anatomical patterns of neurodegeneration as reflected by brain grey matter (GM) alteration. This study aimed to investigate associations between motor subscores and brain GM at voxel level. High resolution structural MRI T1 scans from the Parkinson's Progression Markers Initiative (PPMI) repository were employed to estimate brain GM intensity of PD subjects. Correlations between GM intensity and total MDS-UPDRS III and its four subscores were computed. The total MDS-UPDRS III score was significantly negatively correlated bilaterally with putamen and caudate GM density. Lower anterior striatal GM intensity was significantly associated with higher rigidity subscores, whereas left-sided anterior striatal and precentral cortical GM reduction were correlated with severity of axial symptoms. No significant morphometric associations were demonstrated for tremor subscores. In conclusion, we provide evidence for neuroanatomical patterns underpinning motor symptoms in early PD.

Keywords: MDS-UPDRS III; MRI grey matter; Motor symptoms; PD subtypes; Parkinson's disease.

MeSH terms

  • Aged
  • Brain / pathology*
  • Female
  • Gray Matter / pathology*
  • Humans
  • Hypokinesia / diagnostic imaging
  • Hypokinesia / pathology
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Muscle Rigidity / diagnostic imaging
  • Muscle Rigidity / pathology
  • Parkinson Disease / complications*
  • Parkinson Disease / diagnostic imaging*
  • Parkinson Disease / pathology*
  • Tremor / diagnostic imaging
  • Tremor / pathology