Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2017 Dec 4;16(1):76.
doi: 10.1186/s12937-017-0304-z.

Walnut Consumption in a Weight Reduction Intervention: Effects on Body Weight, Biological Measures, Blood Pressure and Satiety

Affiliations
Free PMC article
Randomized Controlled Trial

Walnut Consumption in a Weight Reduction Intervention: Effects on Body Weight, Biological Measures, Blood Pressure and Satiety

Cheryl L Rock et al. Nutr J. .
Free PMC article

Abstract

Background: Dietary strategies that help patients adhere to a weight reduction diet may increase the likelihood of weight loss maintenance and improved long-term health outcomes. Regular nut consumption has been associated with better weight management and less adiposity. The objective of this study was to compare the effects of a walnut-enriched reduced-energy diet to a standard reduced-energy-density diet on weight, cardiovascular disease risk factors, and satiety.

Methods: Overweight and obese men and women (n = 100) were randomly assigned to a standard reduced-energy-density diet or a walnut-enriched (15% of energy) reduced-energy diet in the context of a behavioral weight loss intervention. Measurements were obtained at baseline and 3- and 6-month clinic visits. Participants rated hunger, fullness and anticipated prospective consumption at 3 time points during the intervention. Body measurements, blood pressure, physical activity, lipids, tocopherols and fatty acids were analyzed using repeated measures mixed models.

Results: Both study groups reduced body weight, body mass index and waist circumference (time effect p < 0.001 for each). Change in weight was -9.4 (0.9)% vs. -8.9 (0.7)% (mean [SE]), for the standard vs. walnut-enriched diet groups, respectively. Systolic blood pressure decreased in both groups at 3 months, but only the walnut-enriched diet group maintained a lower systolic blood pressure at 6 months. The walnut-enriched diet group, but not the standard reduced-energy-density diet group, reduced total cholesterol and low-density lipoprotein cholesterol (LDL-C) at 6 months, from 203 to 194 mg/dL and 121 to 112 mg/dL, respectively (p < 0.05). Self-reported satiety was similar in the groups.

Conclusions: These findings provide further evidence that a walnut-enriched reduced-energy diet can promote weight loss that is comparable to a standard reduced-energy-density diet in the context of a behavioral weight loss intervention. Although weight loss in response to both dietary strategies was associated with improvements in cardiovascular disease risk factors, the walnut-enriched diet promoted more favorable effects on LDL-C and systolic blood pressure.

Trial registration: The trial is registered at ( NCT02501889 ).

Keywords: Blood pressure; Cardiovascular disease risk factors; Nuts; Satiety; Weight loss.

Conflict of interest statement

Ethics approval and consent to participate

The UCSD institutional review board approved the study protocol (#151015), and all participants provided written informed consent. Prior to recruitment and operationalizing the study, the trial was registered at http://www.clinicaltrials.gov (NCT02501889).

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Flow chart for study participants

Similar articles

See all similar articles

Cited by 10 articles

See all "Cited by" articles

References

    1. Jensen MD, Ryan DH, Apovian CM, et al. Guidelines (2013) for managing overweight and obesity in adults. Obesity. 2014;22:i–xvi. doi: 10.1002/oby.20778. - DOI
    1. Fleming JA, Kris-Etherton PM. Macronutrient content of the diet: what do we know about energy balance and weight maintenance? Curr Obes Rep. 2016;5:208–213. doi: 10.1007/s13679-016-0209-8. - DOI - PubMed
    1. Delzenne N, Blundell J, Brouns F, et al. Gastrointestinal targets of appetite regulation in humans. Obes Rev. 2010;11:234–250. doi: 10.1111/j.1467-789X.2009.00707.x. - DOI - PubMed
    1. Mattes RD, Kris-Etherton PM, Foster GD. Impact of peanuts and tree nuts on body weight and healthy weight loss in adults. J Nutr. 2008;138:1741S–1745S. - PubMed
    1. Mattes RD, Dreher ML. Nuts and healthy body weight maintenance mechanisms. Asia Pac J Clin Nutr. 2010;19:137–141. - PubMed

Publication types

Substances

Associated data

Feedback