1 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), INSERM, UMR 1153, Epidemiology of Childhood and Adolescent Cancers Research Group (EPICEA), Paris Descartes University, F-75014 Paris, France. Electronic address: fabienne.marquant@inserm.fr.
2 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), INSERM, UMR 1153, Epidemiology of Childhood and Adolescent Cancers Research Group (EPICEA), Paris Descartes University, F-75014 Paris, France.
3 Institut de Radioprotection et de Sûreté Nucléaire, IRSN, PSE-ENV, SEREN, BERAD, Fontenay aux Roses, France.
4 Institut de Radioprotection et de Sûreté Nucléaire, IRSN, PSE-Sante, SESANE, Fontenay aux Roses, France.
5 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), INSERM, UMR 1153, Epidemiology of Childhood and Adolescent Cancers Research Group (EPICEA), Paris Descartes University, F-75014 Paris, France; French National Registry of Childhood Hematological Malignancies (NRCH), Villejuif, France.
Elements to answer the points raised in the Letter in question are proposed, notably about exposure metrics and their influence on the results and statistical power of epidemiological studies.