The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation

Trends Biochem Sci. 2018 Jan;43(1):4-9. doi: 10.1016/j.tibs.2017.11.001. Epub 2017 Dec 5.


The Rvb1-Rvb2-Tah1-Pih1/prefoldin-like (R2TP/PFDL) complex is a unique chaperone that provides a platform for the assembly and maturation of many key multiprotein complexes in mammalian cells. Here, we propose to rename R2TP/PFDL as PAQosome (particle for arrangement of quaternary structure) to more accurately represent its unique function.

Keywords: R2TP; complex assembly; molecular chaperone; prefoldin; quaternary structure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATPases Associated with Diverse Cellular Activities / metabolism
  • Apoptosis Regulatory Proteins / metabolism
  • Carrier Proteins / metabolism
  • DNA Helicases / metabolism
  • Humans
  • Molecular Chaperones / chemistry*
  • Molecular Chaperones / metabolism*
  • Multiprotein Complexes / biosynthesis
  • Multiprotein Complexes / chemistry*
  • Multiprotein Complexes / metabolism*
  • Protein Structure, Quaternary*


  • Apoptosis Regulatory Proteins
  • Carrier Proteins
  • Molecular Chaperones
  • Multiprotein Complexes
  • PIH1D1 protein, human
  • RPAP3 protein, human
  • ATPases Associated with Diverse Cellular Activities
  • DNA Helicases
  • RUVBL1 protein, human
  • RUVBL2 protein, human

Grants and funding