Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro

Pregnancy Hypertens. 2018 Apr;12:189-193. doi: 10.1016/j.preghy.2017.11.002. Epub 2017 Nov 14.

Abstract

Decidual stromal cells form the largest proportion of maternal cells at the maternal-fetal interface. Our aim was to investigate the role of the pre-eclampsia associated decidual activin receptor, ACVR2A, in regulating trophoblast functions at this interface. St-T1b and HTR-8/SVneo cell lines were used to model decidual stromal and trophoblast cells respectively. St-T1b conditioned medium inhibited HTR-8/SVneo adhesion, proliferation, migration and invasion; all effects that were attenuated by decidual ACVR2A siRNA transfection. These findings suggest that altered decidual ACVR2A expression perturbs the maternal-fetal crosstalk involved in regulating trophoblast function at the interface, which may affect placentation and lead to pre-eclampsia.

Keywords: ACVR2A; Decidual stromal cells; Extravillous trophoblast.

MeSH terms

  • Activin Receptors, Type II / genetics
  • Activin Receptors, Type II / metabolism*
  • Cell Adhesion*
  • Cell Line
  • Cell Movement*
  • Cell Proliferation*
  • Culture Media, Conditioned / metabolism
  • Decidua / metabolism*
  • Decidua / pathology
  • Female
  • Humans
  • Paracrine Communication*
  • Placentation
  • Pre-Eclampsia / genetics
  • Pre-Eclampsia / metabolism
  • Pre-Eclampsia / pathology
  • Pregnancy
  • Signal Transduction
  • Stromal Cells / metabolism*
  • Stromal Cells / pathology
  • Trophoblasts / metabolism*
  • Trophoblasts / pathology

Substances

  • Culture Media, Conditioned
  • Activin Receptors, Type II
  • activin receptor type II-A