ADP-ribosylation of DNA moving into focus

FEBS J. 2017 Dec;284(23):3999-4001. doi: 10.1111/febs.14326.

Abstract

In this issue of The FEBS Journal, Munnur and Ahel describe the reversible mono-ADP-ribosylation of DNA by PARP3, a member of the poly-ADP-ribose-polymerase family known to modify proteins. They demonstrate a selective ADP-ribosylation of the 5'-phosphate group on DNA ends and show that the modification can be reversed by several known ADP-ribosylhydrolases including PARG.

Publication types

  • Comment

MeSH terms

  • ADP-Ribosylation*
  • Adenosine Diphosphate Ribose*
  • DNA
  • DNA Breaks

Substances

  • Adenosine Diphosphate Ribose
  • DNA