Drug dosing in patients with renal insufficiency

Postgrad Med. 1993 Dec;94(8):153-164. doi: 10.1080/00325481.1993.11945776.


Preview When drugs are prescribed for patients with renal insufficiency, the dosage regimen may need to be altered to prevent toxic accumulation of drugs or their metabolites. An increase in the dosing interval is preferred over dose reduction for drugs excreted by the kidney. In this article, the authors explain how renal impairment interferes with the disposition of drugs and present guidelines to reduce drug-induced side effects and improve patient outcomes.