The Effects of Sleep on the Commensal Microbiota: Eyes Wide Open?

J Clin Gastroenterol. 2018 Mar;52(3):204-209. doi: 10.1097/MCG.0000000000000965.


Sleep dysfunction is an epidemic, the implications of which have a profound impact on a variety of gastrointestinal disease. Recent data suggests a relationship between sleep dysfunction and intestinal dysbiosis, a known proinflammatory driver. This article evaluates the interplay between sleep dysfunction and gastrointestinal health and disease, with a focus on the impact of circadian rhythm disruption on the commensal microbiota.

Publication types

  • Review

MeSH terms

  • Animals
  • Circadian Rhythm / physiology
  • Dysbiosis / etiology*
  • Dysbiosis / physiopathology
  • Gastrointestinal Diseases / etiology*
  • Gastrointestinal Diseases / physiopathology
  • Gastrointestinal Microbiome / physiology
  • Humans
  • Sleep Wake Disorders / complications*