Genetic polymorphisms in caveolin-1 associate with breast cancer risk in Chinese Han population

Meng Wang; Tian Tian; Xiaobin Ma; Wenge Zhu; Yan Guo; Zhao Duan; Jiangbo Fan; Shuai Lin; Kang Liu; Yi Zheng; Qianwen Sheng; Zhi-Jun Dai; Huixia Peng

doi:10.18632/oncotarget.21560

Genetic polymorphisms in caveolin-1 associate with breast cancer risk in Chinese Han population

Oncotarget. 2017 Oct 6;8(53):91654-91661. doi: 10.18632/oncotarget.21560. eCollection 2017 Oct 31.

Authors

Meng Wang¹, Tian Tian¹, Xiaobin Ma¹, Wenge Zhu², Yan Guo³, Zhao Duan⁴, Jiangbo Fan⁴, Shuai Lin¹, Kang Liu¹, Yi Zheng¹, Qianwen Sheng¹, Zhi-Jun Dai¹, Huixia Peng⁴

Affiliations

¹ Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
² Department of Biochemistry and Molecular Medicine, The George Washington University Medical School, Washington, DC, USA.
³ School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
⁴ Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Abstract

Caveolin-1(CAV-1) was demonstrated to be a tumor suppressor gene and be implicated in the development of breast cancer (BC). Numerous potentially functional polymorphisms in CAV-1 have been identified, but their effects on BC were not clear. This case-control study aims to evaluate the relationship between CAV-1 polymorphisms and BC risk. 560 BC patients and 583 healthy controls were enrolled in the present study, all from Chinese Han population. We detected 3 single nucleotide polymorphisms (rs3807987, rs1997623, and rs7804372) in CAV-1 using the Sequenom MassARRAY method. The association between CAV-1genotypes and BC risk was assessed in six genetic models by calculating the odds ratio (OR) and 95% confidence intervals (95% CIs) with χ²-test. The CAV-1 rs3807987 polymorphism was observed to increase the risk of BC And the A allele of rs3807987 relates to a larger tumor size (≥2cm) and lower incidence of PR-positive BC while the AA genotype of rs7804372 associates with a higher ER and Her-2 positive rate among BC patients. In addition, A_rs1997623G_rs3807987T_rs7804372 haplotype was linked to a decreased risk of BC (OR =0.64, 95%CI=0.44-0.93), whereas C_rs1997623A_rs3807987T_rs7804372 haplotype was related to an increased BC risk (OR =1.74, 95%CI=1.04-2.92). Our study suggests that CAV-1 rs3807987 can increase the BC risk among Chinese Han women. And the rs3807987 and rs7804372 in CAV-1 may serve as predictors for prognosis of BC.

Keywords: breast cancer; caveolin-1; polymorphism; risk.

Abstract

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