Psoriasis in Skin of Color: Insights Into the Epidemiology, Clinical Presentation, Genetics, Quality-of-Life Impact, and Treatment of Psoriasis in Non-White Racial/Ethnic Groups

Am J Clin Dermatol. 2018 Jun;19(3):405-423. doi: 10.1007/s40257-017-0332-7.

Abstract

Psoriasis is a chronic inflammatory skin condition affecting diverse racial/ethnic groups throughout the world. Large population-based studies suggest that psoriasis occurs most often in individuals of European ancestry, followed by black and Hispanic individuals, although the true prevalence of psoriasis in non-white individuals is likely underestimated. Despite similarities in psoriasis between ethnic groups, there are notable differences in the presentation, quality-of-life impact, and treatment of psoriasis with important implications for the management of non-white individuals. Overall, heterogeneity in psoriasis susceptibility alleles, in combination with cultural and socioeconomic factors, may explain these differences. In this article, we review the epidemiology, clinical presentation, genetic polymorphisms, quality-of-life impact, and treatment nuances of psoriasis in patients with skin of color.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Administration, Topical
  • Biological Products / therapeutic use
  • Dermatologic Agents / pharmacology
  • Dermatologic Agents / therapeutic use*
  • Ethnic Groups / genetics
  • Ethnic Groups / statistics & numerical data*
  • Humans
  • Phototherapy / methods
  • Polymorphism, Genetic
  • Psoriasis / ethnology*
  • Psoriasis / genetics
  • Psoriasis / pathology
  • Psoriasis / therapy
  • Quality of Life*
  • Skin / drug effects
  • Skin / pathology
  • Skin Pigmentation*
  • Treatment Outcome

Substances

  • Biological Products
  • Dermatologic Agents