Similarity and Differences in Inflammation-Related Characteristics of the Peripheral Immune System of Patients with Parkinson's and Alzheimer's Diseases

Int J Mol Sci. 2017 Dec 6;18(12):2633. doi: 10.3390/ijms18122633.


Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common age-related neurodegenerative disorders. Both diseases are characterized by chronic inflammation in the brain-neuroinflammation. The first signs of PD and AD are most often manifested in old age, in which the immune system is usually characterized by chronic inflammation, so-called "inflammaging" In recent years, there is growing evidence that pathogenesis of these diseases is connected with both regional and peripheral immune processes. Currently, the association of clinical signs of PD and AD with different characteristics of patient immune status is actively being researched. In this mini-review we compare the association of PD and AD alterations of a number of immune system parameters connected with the process of inflammation.

Keywords: Alzheimer’s disease; Parkinson’s disease; cytokines; inflammation; neuroinflammation; oxidative stress; peripheral immune system.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / blood*
  • Alzheimer Disease / immunology
  • Biomarkers / blood
  • Cytokines / blood*
  • HSP70 Heat-Shock Proteins / blood
  • Humans
  • Inflammation / blood
  • Inflammation / immunology
  • Oxidative Stress
  • Parkinson Disease / blood*
  • Parkinson Disease / immunology


  • Biomarkers
  • Cytokines
  • HSP70 Heat-Shock Proteins