Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle

Inmaculada Martínez-Reyes; Navdeep S Chandel

doi:10.1016/j.cmet.2017.11.005

Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle

Cell Metab. 2017 Dec 5;26(6):803-804. doi: 10.1016/j.cmet.2017.11.005.

Authors

Inmaculada Martínez-Reyes¹, Navdeep S Chandel²

Affiliations

¹ Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
² Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: nav@northwestern.edu.

PMID: 29211977
DOI: 10.1016/j.cmet.2017.11.005

Abstract

Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors.

Publication types

Comment

MeSH terms

Citric Acid Cycle
Glucose*
Lactic Acid*
Mitochondria
Oxidation-Reduction

Substances

Lactic Acid
Glucose

Grants and funding

P01 AG049665/AG/NIA NIH HHS/United States