RevAMPing Mitochondrial Shape to Live Longer

Cell Metab. 2017 Dec 5;26(6):805-806. doi: 10.1016/j.cmet.2017.11.010.

Abstract

Whether and how mitochondria connect reduced energy intake to healthy aging are unclear. In this issue of Cell Metabolism, Weir et al. (2017) find that constitutive AMPK activation and dietary restriction promote longevity in C. elegans via remodeling of the mitochondrial network and fatty acid oxidation in peripheral tissues.

Publication types

  • Comment

MeSH terms

  • AMP-Activated Protein Kinases
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins*
  • Longevity*
  • Mitochondria
  • Peroxisomes

Substances

  • Caenorhabditis elegans Proteins
  • AMP-Activated Protein Kinases