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doi: 10.1016/j.str.2017.11.009.
Structural Insight into a Fatty-Acyl Chaperone for Wnt Proteins
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- PMID: 29211982
- DOI: 10.1016/j.str.2017.11.009
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Structural Insight into a Fatty-Acyl Chaperone for Wnt Proteins
Structure.
.
Free article
Abstract
Wnt signaling proteins are fatty-acylated and bind to the protein afamin. The afamin-Wnt complex increases Wnt solubility dramatically and is likely involved in Wnt trafficking. In this issue of Structure, Naschberger et al. (2017) determine the crystal structure of afamin in complex with palmitoleic acid, revealing how afamin binds palmitoleoylated Wnt.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Comment on
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Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport.Structure. 2017 Dec 5;25(12):1907-1915.e5. doi: 10.1016/j.str.2017.10.006. Epub 2017 Nov 16. Structure. 2017. PMID: 29153507
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