Phenelfamycins, a novel complex of elfamycin-type antibiotics. III. Activity in vitro and in a hamster colitis model

R N Swanson; D J Hardy; N L Shipkowitz; C W Hanson; N R Ramer; L J Coen; P B Fernandes

doi:10.7164/antibiotics.42.94

Phenelfamycins, a novel complex of elfamycin-type antibiotics. III. Activity in vitro and in a hamster colitis model

J Antibiot (Tokyo). 1989 Jan;42(1):94-101. doi: 10.7164/antibiotics.42.94.

Authors

R N Swanson¹, D J Hardy, N L Shipkowitz, C W Hanson, N R Ramer, L J Coen, P B Fernandes

Affiliation

¹ Anti-infective Research Division, Abbott Laboratories, Illinois.

PMID: 2921230
DOI: 10.7164/antibiotics.42.94

Abstract

Phenelfamycins A, B, C, E, F and unphenelfamycin make up a recently isolated group of elfamycin-type antibiotics. All of the phenelfamycins were active against Gram-positive anaerobes, including Clostridium difficile. Phenelfamycin A was also active in vitro against Neisseria gonorrhoeae and Streptococci. Phenelfamycin A was found to be effective in prolonging the survival of hamsters in an animal model of C. difficile enterocolitis. After oral administration of phenelfamycin A to hamsters, antibiotic was detected in the caecal contents but not in the blood.

MeSH terms

Aminoglycosides*
Animals
Anti-Bacterial Agents / pharmacokinetics
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Bacteria / drug effects
Clostridium Infections / drug therapy*
Cricetinae
Enterocolitis / drug therapy*
Male
Mesocricetus
Vancomycin / therapeutic use

Substances

Aminoglycosides
Anti-Bacterial Agents
phenelfamycin F
phenelfamycin E
unphenelfamycin
phenelfamycin A
phenelfamycin B
phenelfamycin C
Vancomycin