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Review
, 2017, 2605628

Current Tissue Molecular Markers in Colorectal Cancer: A Literature Review

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Review

Current Tissue Molecular Markers in Colorectal Cancer: A Literature Review

Gaia Peluso et al. Biomed Res Int.

Abstract

Background: Colorectal cancer (CRC) is one of the most spread neoplasia types all around the world, especially in western areas. It evolves from precancerous lesions and adenomatous polyps, through successive genetic and epigenetic mutations. Numerous risk factors intervene in its development and they are either environmental or genetic.

Aim of the review: Alongside common screening techniques, such as fecal screening tests, endoscopic evaluation, and CT-colonography, we have identified the most important and useful biomarkers and we have analyzed their role in the diagnosis, prevention, and prognosis of CRC.

Conclusion: Biomarkers can become an important tool in the diagnostic and therapeutic process for CRC. But further studies are needed to identify a noninvasive, cost-effective, and highly sensible and specific screening test for their detection and to standardize their use in clinical practice.

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References

    1. Marley A. R., Nan H. Epidemiology of colorectal cancer. International Journal of Molecular Epidemiology and Genetics. 2016;7(3):105–114. - PMC - PubMed
    1. Haggar F. A., Boushey R. P. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clinics in Colon and Rectal Surgery. 2009;22(4):191–197. doi: 10.1055/s-0029-1242458. - DOI - PMC - PubMed
    1. Shussman N., Wexner S. D. Colorectal polyps and polyposis syndromes. Gastroenterology Report. 2014;2(1):1–15. doi: 10.1093/gastro/got041. - DOI - PMC - PubMed
    1. Carlomagno N., Schonauer F., Tammaro V., Di Martino A., Criscitiello C., Santangelo M. L. A multidisciplinary approach to an unusual medical case of locally advanced gastric cancer: a case report. Journal of Medical Case Reports. 2015;9:p. 13. doi: 10.1186/1752-1947-9-13. - DOI - PMC - PubMed
    1. Santangelo M., Esposito A., Tammaro V., et al. What indication, morbidity and mortality for central pancreatectomy in oncological surgery? A systematic review. International Journal of Surgery. 2016;28:S172–S176. doi: 10.1016/j.ijsu.2015.12.046. - DOI - PubMed

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