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, 54 (14), 1710-1713

DNAzyme Based Visual Detection of DNA Methylation

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DNAzyme Based Visual Detection of DNA Methylation

Mei Li et al. Chem Commun (Camb).

Abstract

A novel colorimetric method which utilizes DNAzyme as a signal reporter was developed for DNA methylation detection. As low as 1/106 of methylated DNA could be successfully detected from unmethylated DNA. The discrimination ability is at least two orders of magnitude better than that of the methylation specific PCR.

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